rabbit polyclonal anti ctip antibody (Novus Biologicals)
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Novus Biologicals
rabbit polyclonal anti ctip antibody
Rabbit Polyclonal Anti Ctip Antibody, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 91/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti ctip antibody/product/Novus Biologicals
Average 91 stars, based on 8 article reviews
Rabbit Polyclonal Anti Ctip Antibody, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 91/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti ctip antibody/product/Novus Biologicals
Average 91 stars, based on 8 article reviews
rabbit polyclonal anti ctip antibody - by Bioz Stars,
2026-03
91/100 stars
Images
1) Product Images from "DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination"
Article Title: DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination
Journal: Nature Communications
doi: 10.1038/s41467-021-24341-z
Figure Legend Snippet: a Fluorescent image (left panel) and quantification (right panel) showing the decreased formation of RAD51 foci in control U2OS cells (red) and cells knocked down for DHX9 (blue) treated with 1 μM camptothecin for 2 h then left for 2 h to recover. b DHX9 is in a common genetic pathway for the formation of RPA foci with CTIP and MRE11. RPA foci in cells knocked down using siRNA for the indicated genes are shown. Cells were treated with 1 μM camptothecin for 2 h. c Recruitment of DHX9 to foci is dependent on ATM and ATR. Wild-type cells were inhibited for ATR and ATM using VE-821 and KU55933, respectively. d , e DHX9 is in a common genetic pathway for the formation of RPA foci with ATR and ATM. RPA foci are shown for cells treated with inhibitors for ATR (VE-821) and ATM (KU55933) ( d ) or knocked down with siRNA against ATM and ATR ( e ). f Western blot showing that knockdown of DHX9 impairs Cpt induced autophosphorylation of ATR on Thr1989 and phosphorylation of Chk1 on ser 345. Quantification of n cells (as indicated) from three pooled biologically independent experiments were performed in ( a – e ). Means of data sets were shown to be significantly different using one-way ANOVA with Tukey’s post hoc test. (ns not significant, * p < 0.1, ** p < 0.01, *** p < 0.001, and **** p < 0.0001). Error bars indicating one standard deviation are also indicated. Source data are provided as a Source Data file.
Techniques Used: Control, Western Blot, Knockdown, Phospho-proteomics, Standard Deviation
Figure Legend Snippet: a Fluorescence images (left panel) and graph (right panel) showing that localization of BLM to camptothecin-induced DNA damage foci is impaired in cells knocked down for DHX9. b Fluorescence images (left panel) and graph (right panel) showing that localization of CTIP to camptothecin-induced DNA damage foci is impaired in cells knocked down for DHX9. Quantification of n cells (as indicated) from three pooled biologically independent experiments were performed in ( a ) and ( b ). Means were shown to be significantly different using one-way ANOVA with post hoc Tukey’s test (**** p < 0.0001). c Western blot of fractionated cell extracts showing that localization of BLM and CTIP to chromatin (P1 fraction) in response to camptothecin-induced DNA damage is reduced in cells knocked down for DHX9. Localization of BLM and CTIP in cytoplasmic (S1) and nuclear fractions (S2) is not decreased. Histone H3 is shown as a marker of S2 and P1 fractions. d DNA synthesis is impaired in DHX9 and BRCA1 deficient cells treated with camptothecin (5 μM for 2 h). This defect is not suppressed by knockdown of 53BP1 Right panel shows representative images for the incorporation of CldU and IdU nucleotide analogs as well as merged images. The left panel shows graphical data of cells stained with both CldU and IldU as a percentage of total cells stained with CldU. Graphs include data from three biologically independent experiments. Mean and error bars indicating one standard deviation are also indicated. Statistical significance for all experiments was demonstrated using one-way ANOVA with post hoc Tukey’s test (**** p < 0.0001, * p < 0.1, ns not significant). Source data are provided as a Source Data file.
Techniques Used: Fluorescence, Western Blot, Marker, DNA Synthesis, Knockdown, Staining, Standard Deviation
